doi: 10.3181/00379727-148-38724.
Effect of ascorbic acid on rhinovirus replication in WI-38 cells
- PMID: 165544
- DOI: 10.3181/00379727-148-38724
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Effect of ascorbic acid on rhinovirus replication in WI-38 cells
Proc Soc Exp Biol Med.
1975 Apr.
Abstract
Exposure of WI-38 cells to ascorbic acid plus glutathione mixtures in growth medium for 2 days prior to infection with rhinovirus serotype 20 and during virus replication suppressed multicyclic but not single-cycle growth of the virus. Multicyclic growth was suppressed over the range of multiplicity of infection (m.o.i.) of 4 times 10-minus 1 minus 4 times 10-minus 4 PFU/cell. There was some suggestion that, in the presence of ascorbic acid plus glutathione, interferon was produced at the highest m.o.i. tested but at barely detectable levels.
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