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. 1975 Apr;148(4):1237-43.
doi: 10.3181/00379727-148-38724.

Effect of ascorbic acid on rhinovirus replication in WI-38 cells

P R Schwerdt, C E Schwerdt

Effect of ascorbic acid on rhinovirus replication in WI-38 cells

P R Schwerdt et al. Proc Soc Exp Biol Med. 1975 Apr.

Abstract

Exposure of WI-38 cells to ascorbic acid plus glutathione mixtures in growth medium for 2 days prior to infection with rhinovirus serotype 20 and during virus replication suppressed multicyclic but not single-cycle growth of the virus. Multicyclic growth was suppressed over the range of multiplicity of infection (m.o.i.) of 4 times 10-minus 1 minus 4 times 10-minus 4 PFU/cell. There was some suggestion that, in the presence of ascorbic acid plus glutathione, interferon was produced at the highest m.o.i. tested but at barely detectable levels.

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