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. 1991 Apr 25;206(4):343-6.
doi: 10.1016/0922-4106(91)90120-7.

Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis

L Agulló  1 , A García
Affiliations

Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis

L Agulló et al. Eur J Pharmacol. .

Abstract

Norepinephrine induces a rapid and concentration-dependent rise (EC50 = 1.21 +/- 0.33 microM) in cyclic GMP levels in astrocyte-enriched cultures from rat brain. The response is partially mediated by alpha 1-adrenoceptors since a marked inhibition is observed in the presence of prazosin while the beta-antagonist propranolol shows a smaller effect and the alpha 2-antagonist yohimbine is ineffective. L-NG-methylarginine, an inhibitor of nitric oxide synthesis from L-arginine, blocks the norepinephrine-induced cyclic GMP accumulation. This effect is reversed by L-arginine.

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