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Review
. 2005 Aug;1(4):449-60.
doi: 10.2217/14796694.1.4.449.

Targeting HER1/EGFR in cancer therapy: experience with erlotinib

Giuseppe Giaccone  1
Affiliations
Review

Targeting HER1/EGFR in cancer therapy: experience with erlotinib

Giuseppe Giaccone. Future Oncol. 2005 Aug.

Abstract

Research into the role of the human epidermal receptor growth factor receptor 1/epidermal growth factor receptor (HER1/EGFR) in tumorigenesis has generated a new class of anticancer drugs. One such agent, erlotinib (Tarceva), is a potent, selective and reversible inhibitor of HER1/EGFR tyrosine kinase activity. Erlotinib has demonstrated the clinical activity in a variety of solid tumors, and has recently demonstrated improvements in survival in large Phase III trials, in non-small-cell lung cancer and pancreatic cancer.

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