Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Mar 24;311(5768):1774-5.
doi: 10.1126/science.1123510.

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration

Anita S Chong  1 , Jikun Shen, Jing Tao, Dengping Yin, Andrey Kuznetsov, Manami Hara, Louis H Philipson
Affiliations

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration

Anita S Chong et al. Science. .

Abstract

Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.

PubMed Disclaimer

Comment in

MeSH terms