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. 1970 Jun;1(6):600-3.
doi: 10.1128/iai.1.6.600-603.1970.

Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis

R J Patterson  1 , G P Youmans
Affiliations

Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis

R J Patterson et al. Infect Immun. 1970 Jun.

Abstract

We have shown that splenic lymphocytes from mice immunized with viable attenuated mycobacterial cells (H37Ra) or ribonucleic acid prepared from these cells will bring about inhibition of multiplication of virulent tubercle bacilli (H37Rv) within normal mouse peritoneal macrophages in tissue culture. Apparently these lymphocytes, when stimulated with viable virulent tubercle bacilli, elaborate a filterable substance(s) which is responsible for this intracellular growth inhibitory effect.

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References

    1. Infect Immun. 1970 Jan;1(1):30-40 - PubMed
    1. Am Rev Respir Dis. 1965 Apr;91:499-509 - PubMed
    1. Am Rev Respir Dis. 1965 Apr;91:488-98 - PubMed
    1. Blood. 1964 Jun;23:811-28 - PubMed
    1. Am Rev Tuberc. 1959 Feb;79(2):221-31 - PubMed

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