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. 1970 Oct;2(4):443-7.
doi: 10.1128/iai.2.4.443-447.1970.

Plaque reduction technique for demonstrating neutralizing antibodies for Chlamydia

J Banks  1 , B Eddie, M Sung, N Sugg, J Schachter, K F Meyer
Affiliations

Plaque reduction technique for demonstrating neutralizing antibodies for Chlamydia

J Banks et al. Infect Immun. 1970 Oct.

Abstract

Some members of the genus Chlamydia (Bedsonia or psittacosis-lymphogranuloma venereum-trachoma-inclusion conjunctivitis group of microorganisms) produce plaques in monolayers of mouse fibroblast (L-929) cells. Hyperimmune chicken antisera may be capable of specifically reducing plaque counts. When the test was applied to chlamydiae isolated from avian species, the results indicated that different isolates with a common source had similar antigenic reactivity. The plaque reduction test is a potentially useful method for serotyping chlamydiae. The difficult aspect of the method appears to be a readily reproducible means of producing neutralizing antiserum.

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References

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