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. 1971 Feb;3(2):268-73.
doi: 10.1128/iai.3.2.268-273.1971.

Age-dependent resistance of mice to sindbis virus infection: viral replication as a function of host age

A B Reinarz  1 , M G Broome, B P Sagik
Affiliations

Age-dependent resistance of mice to sindbis virus infection: viral replication as a function of host age

A B Reinarz et al. Infect Immun. 1971 Feb.

Abstract

The development of resistance of outbred white mice to two plaque size variants of Sindbis virus was studied as a function of host age. A sudden drop in mortality occurred over a 3-day period. As little as 1 plaque-forming unit (PFU) per mouse was lethal in 1-day-old animals, whereas inocula of 10(9) PFU per mouse failed to produce high mortality in weanlings. A comparison of viral growth kinetics shows that early replication was similar in newborns and weanlings but that after 6 to 8 hr the production rate and, therefore, the maximal viral titer were suppressed in weanlings. The data demonstrate a lethal viral threshold. Titers in excess of this level lead to mortality, whereas those below it allow survival.

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