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. 1971 Mar;3(3):385-9.
doi: 10.1128/iai.3.3.385-389.1971.

Group a streptococcal polysaccharide antigens

T Matsuno  1 , H D Slade
Affiliations

Group a streptococcal polysaccharide antigens

T Matsuno et al. Infect Immun. 1971 Mar.

Abstract

Cold trichloroacetic acid extracts of group A, type 3 streptococci were fractionated on Sephadex G50 and ECTEOLA cellulose columns. A glucose-N-acetylglucosamine polymer was isolated and shown by chemical, electrophoretic, and antigenic analysis to be distinct from the group A polysaccharide. The antigenic specificity was due to the glucosamine. A glycerol-phosphate-alanine-glucosamine teichoic acid polymer was isolated. The antigenic specificity was due to N-acetylglucosamine and d-alanine methyl ester, with the former possessing principal responsibility. The glucosamine and ester-linked alanine appear to be labile to the method of extraction and fractionation. Group A streptococcal whole cell antiserum, after adsorption with cells of a heterologous serological group and group A polysaccharide antigen, contained antibodies against both polymers.

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