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. 1974 Nov;10(5):1023-8.
doi: 10.1128/iai.10.5.1023-1028.1974.

Interferon synthesis in x-irradiated animals v. Origin of mouse serum interferon induced by polyinosinic-polycytidylic Acid and encephalomyocarditis virus

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Interferon synthesis in x-irradiated animals v. Origin of mouse serum interferon induced by polyinosinic-polycytidylic Acid and encephalomyocarditis virus

P Jullien et al. Infect Immun. 1974 Nov.

Abstract

The radioresistant cell systems producing serum interferon after intravenous administration of polyinosinic-polycytidylic acid [poly(I.C)] or encephalomyocarditis virus in mice were studied in rat-to-mouse radiation chimeras. Interferon induced by poly(I.C) became of donor type within 3 months after grafting of irradiated C3H/He mice with Wistar rat bone marrow cells; this indicated that it was made in cells derived from the hemopoietic system. In contrast, encephalomyocarditis virus-induced interferon remained of recipient type in xenogeneic chimeras up to 3 months after grafting, which indicated that the bulk of this interferon originated from a cell population not derived from the hemopoietic system. To ascertain that the respective radiosensitivities of the systems producing rat interferon in chimeras corresponded to that of normal mice, some rat-to-mouse chimeras were subjected to a second X irradiation 1 month after the first irradiation and restoration. Circulating interferon production was studied 4 days later. As expected, the re-irradiation strongly depressed rat serum interferon production induced by Newcastle disease virus but had no effect on rat interferon synthesis induced by poly (I.C). These results point to a macrophage origin for the bulk of poly(I.C)-induced circulating interferon.

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References

    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1966;11(6):567-76 - PubMed
    1. Nat New Biol. 1971 Feb 17;229(7):212-4 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1967;13(5):417-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Jul;63(3):732-9 - PubMed
    1. J Exp Med. 1965 Jan 1;121:153-70 - PubMed

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