doi: 10.1084/jem.174.4.815.
Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
Affiliations
- PMID: 1655946
- PMCID: PMC2118971
- DOI: 10.1084/jem.174.4.815
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Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
J Exp Med.
.
Abstract
In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement.
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