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. 1991 Jul 24;106(1):75-85.
doi: 10.1007/BF00231191.

A 20 kDa erythrocyte membrane phosphoprotein

S Lee  1 , E B Cunningham, N I Swislocki
Affiliations

A 20 kDa erythrocyte membrane phosphoprotein

S Lee et al. Mol Cell Biochem. .

Abstract

A small (approximately 20 kDa) protein associated with the human erythrocyte membrane undergoes phosphorylation that is potentiated by the addition of phosphatidylinositol. It is indicated that phosphatidylinositol 4.5-bisphosphate, generated in situ during the protein phosphorylation reaction. is the effective agent. Phosphorylation of the small protein is also potentiated when isolated membranes are exposed to conditions that promote the phosphorylation of the phosphatidylinositols. It is suggested that the 20 kDa membrane protein participates in biochemical signaling in the erythrocyte.

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