Review
[Epstein-Barr-virus-induced lymphoproliferative diseases]
[Article in
German]
Affiliations
- PMID: 1656248
Item in Clipboard
Review
[Epstein-Barr-virus-induced lymphoproliferative diseases]
[Article in
German]
Monatsschr Kinderheilkd.
1991 Jul.
Abstract
Infections with EBV are of increasing importance in pediatrics. Molecular and immunological methods have led to important advances in our understanding of the biological properties of this virus and the immunological consequences to its host. EBV-associated lymphoproliferative disorders mainly arise in immunodeficient patients by the unchecked polyclonal outgrowth of EBV-infected B-cells. On the other hand, primary genetic changes in B-cells (chromosomal translocation and oncogene deregulation) may also lead to induction of monoclonal lymphoma.
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