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. 2006 Mar;69(3):369-72.
doi: 10.1021/np050406v.

Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

Zakaria H Mbwambo  1 , Modest C Kapingu, Mainen J Moshi, Francis Machumi, Sandra Apers, Paul Cos, Daneel Ferreira, Jannie P J Marais, Dirk Vanden Berghe, Louis Maes, Arnold Vlietinck, Luc Pieters
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Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

Zakaria H Mbwambo et al. J Nat Prod. 2006 Mar.

Abstract

A new biflavanoid, ent-naringeninyl-(I-3alpha,II-8)-4'-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC(50) 6.7 microM). Antitrypanosomal activity (IC(50) 0.87 microM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM).

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