doi: 10.1016/j.bmcl.2006.02.073.
Epub 2006 Mar 24.
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase
Affiliations
- PMID: 16563755
- DOI: 10.1016/j.bmcl.2006.02.073
Item in Clipboard
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase
Bioorg Med Chem Lett.
.
Abstract
The first mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from D-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.
Similar articles
-
Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase.Carbohydr Res. 2005 Mar 21;340(4):529-37. doi: 10.1016/j.carres.2004.11.019. Carbohydr Res. 2005. PMID: 15721322
-
Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.Bioorg Med Chem Lett. 2011 Sep 1;21(17):5092-7. doi: 10.1016/j.bmcl.2011.03.071. Epub 2011 Apr 12. Bioorg Med Chem Lett. 2011. PMID: 21493065
-
Steady-state kinetics and inhibitor binding of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tryptophan sensitive) from Escherichia coli.Biochemistry. 1997 Dec 16;36(50):15817-22. doi: 10.1021/bi971135t. Biochemistry. 1997. PMID: 9398312
-
Evolution and phylogenetic distribution of the specialized isozymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in superfamily-B prokaryotes.Microbiol Sci. 1988 Oct;5(10):316-9. Microbiol Sci. 1988. PMID: 2908556 Review.
-
Unique biosynthesis of dehydroquinic acid?Bioorg Chem. 2004 Oct;32(5):309-15. doi: 10.1016/j.bioorg.2004.06.003. Bioorg Chem. 2004. PMID: 15381397 Review.
Cited by
-
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.J Biol Chem. 2011 May 6;286(18):16197-207. doi: 10.1074/jbc.M110.211649. Epub 2011 Mar 15. J Biol Chem. 2011. PMID: 21454647 Free PMC article.
-
Functionalization of α-hydroxyphosphonates as a convenient route to N-tosyl-α-aminophosphonates.RSC Adv. 2018 Mar 27;8(22):11957-11974. doi: 10.1039/c8ra01656a. eCollection 2018 Mar 26. RSC Adv. 2018. PMID: 35539392 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
