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. 1991 Oct 11;19(19):5285-91.
doi: 10.1093/nar/19.19.5285.

An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1

S Nicolis  1 , C Bertini, A Ronchi, S Crotta, L Lanfranco, E Moroni, B Giglioni, S Ottolenghi
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Free PMC article

An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1

S Nicolis et al. Nucleic Acids Res. .
Free PMC article

Abstract

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.

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References

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