Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct 11;19(19):5285-91.
doi: 10.1093/nar/19.19.5285.

An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1

S Nicolis  1 , C Bertini, A Ronchi, S Crotta, L Lanfranco, E Moroni, B Giglioni, S Ottolenghi
Affiliations
Free PMC article

An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1

S Nicolis et al. Nucleic Acids Res. .
Free PMC article

Abstract

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nucleic Acids Res. 1990 Dec 11;18(23):6863-9 - PubMed
    1. Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 - PubMed
    1. Genes Dev. 1991 Jun;5(6):919-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3004-8 - PubMed
    1. Nature. 1991 Jan 17;349(6306):257-60 - PubMed

Publication types

MeSH terms

Substances