LRP6 holds the key to the entry of anthrax toxin
- PMID: 16564002
- DOI: 10.1016/j.cell.2006.03.007
LRP6 holds the key to the entry of anthrax toxin
Abstract
In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two previously identified receptors for anthrax toxin.
Comment on
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The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.Cell. 2006 Mar 24;124(6):1141-54. doi: 10.1016/j.cell.2005.12.045. Cell. 2006. PMID: 16564009
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