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Review
. 2006 Mar 24;124(6):1121-3.
doi: 10.1016/j.cell.2006.03.004.

Connecting cancer to the asymmetric division of stem cells

Andreas Wodarz  1 , Cayetano Gonzalez
Affiliations
Free article
Review

Connecting cancer to the asymmetric division of stem cells

Andreas Wodarz et al. Cell. .
Free article

Abstract

Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.

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