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Comment
. 2006 Mar 27;172(7):963-5.
doi: 10.1083/jcb.200603015.

Controversy fuels trafficking of GPI-anchored proteins

Sebastian Schuck  1 , Kai Simons
Affiliations
Comment

Controversy fuels trafficking of GPI-anchored proteins

Sebastian Schuck et al. J Cell Biol. .

Abstract

The model that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) take a direct transport route to the apical membrane of epithelial cells has recently been challenged. In this issue, Paladino et al. (p. 1023) and Hua et al. (p. 1035) show that the original view nevertheless holds. This closes a chapter in the winding story of GPI-AP trafficking but opens another phase, as the controversy has stimulated the development of new methodology.

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Figures

Figure 1.
Figure 1.
MDCK cells form polarized epithelial monolayers. The apical membrane (red) and the basolateral membrane (blue) are separated by tight junctions (black).
Figure 2.
Figure 2.
GPI-AP trafficking can be reprogrammed during differentiation. In polarizing MDCK cells, GPI-APs (red) are increasingly targeted to the apical membrane. This could be accompanied by a down-regulation of transcytotic apical delivery.
See this image and copyright information in PMC

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