Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Apr 4;103(14):5249-50.
doi: 10.1073/pnas.0601373103. Epub 2006 Mar 27.

How TRIM5alpha defends against retroviral invasions

Michael Emerman  1
Affiliations
Comment

How TRIM5alpha defends against retroviral invasions

Michael Emerman. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: No conflicts declared.

Figures

Fig. 1.
Fig. 1.
Proposed mechanism of Trim5α. HIV (at left) enters a cell by membrane fusion and deposits its core (yellow) containing viral RNA (red) and other viral proteins into the cytoplasm. Trim5α (green) binds to the mutimeric CA on the viral core and leads to accelerated uncoating (free CA monomers as yellow circles). This activity prevents reverse transcription (RT) of the viral RNA into proviral DNA.
See this image and copyright information in PMC

Comment on

References

    1. Bieniasz P. D. Nat. Immunol. 2004;5:1109–1115. - PubMed
    1. Stremlau M., Perron M., Lee M., Li Y., Song B., Javanbakht H., Diaz-Griffero F., Anderson D. J., Sundquist W. I., Sodroski J. Proc. Natl. Acad. Sci. USA. 2006;103:5514–5519. - PMC - PubMed
    1. Stremlau M., Owens C. M., Perron M. J., Kiessling M., Autissier P., Sodroski J. Nature. 2004;427:848–853. - PubMed
    1. Meroni G., Diez-Roux G. BioEssays. 2005;27:1147–1157. - PubMed
    1. Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., et al. EMBO J. 2001;20:2140–2151. - PMC - PubMed

Substances

LinkOut - more resources