doi: 10.1021/ja060126h.
Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes
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- PMID: 16568997
- DOI: 10.1021/ja060126h
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Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes
J Am Chem Soc.
.
Abstract
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits beta-hydride elimination.
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