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. 2006 Apr 5;128(13):4246-7.
doi: 10.1021/ja060126h.

Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes

Forrest E Michael  1 , Brian M Cochran
Affiliations

Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes

Forrest E Michael et al. J Am Chem Soc. .

Abstract

A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits beta-hydride elimination.

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