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. 2006 Apr;50(4):1531-4.
doi: 10.1128/AAC.50.4.1531-1534.2006.

Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine

P Agnamey  1 , P Brasseur, P Eldin de Pecoulas, Michel Vaillant, P Olliaro
Affiliations

Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine

P Agnamey et al. Antimicrob Agents Chemother. 2006 Apr.

Abstract

We have monitored the in vitro sensitivities of Plasmodium falciparum isolates predeployment and during the deployment of artesunate plus amodiaquine treatment in Mlomp, Casamance (southwestern Senegal) during 2000 to 2004. Parasites remained susceptible to both drugs. Chloroquine resistance levels were high but stable. Quinine continues to be effective.

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Figures

FIG. 1.
FIG. 1.
Box plots of log-transformed IC50s (in nM) for chloroquine (a), quinine (b), monodesethyl amodiaquine (c), and artemisinin (d) by year (1997 and 2000 to 2004). The percentages of isolates above the cutoff value for in vitro resistance (dotted horizontal lines) are displayed for each drug. The top (or the base) of the whisker corresponds to the largest (or the lowest) observed value within the 1.5× interquartile range (IQ) from the 75th (or 25th) percentile. □, mean; ⋄, values outside 1.5× IQ.
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