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. 2006 Apr;50(4):1599-602.
doi: 10.1128/AAC.50.4.1599-1602.2006.

Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients

Emma Bishop  1 , Sharmila Melvani, Benjamin P Howden, Patrick G P Charles, M Lindsay Grayson
Affiliations

Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients

Emma Bishop et al. Antimicrob Agents Chemother. 2006 Apr.

Abstract

We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.

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