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Review
. 1991 Aug;18(3 Suppl):411-3.
doi: 10.1017/s031716710003256x.

Neuronal loss in a lower motor neuron disease induced by a murine retrovirus

P Jolicoeur  1
Affiliations
Review

Neuronal loss in a lower motor neuron disease induced by a murine retrovirus

P Jolicoeur. Can J Neurol Sci. 1991 Aug.

Abstract

An animal model of neuronal loss induced by a murine retrovirus is described. The neurological disease is manifested by a lower limb paralysis and is characterized as a spongiform myeloencephalopathy. The primary determinant of neurovirulence has been mapped within the viral env sequences and a secondary determinant is present within the LTR region. A model of pathogenesis, suggesting that the disease is receptor-mediated, is proposed.

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