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. 2006 Apr;17(2):230-2.
doi: 10.1016/j.semcdb.2006.02.001. Epub 2006 Feb 23.

ITP

Michael Whitaker  1
Affiliations

ITP

Michael Whitaker. Semin Cell Dev Biol. 2006 Apr.

Abstract

I describe how we came to microinject inositol trisphosphate into sea urchin eggs and found that is was a very potent activator of calcium release.

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Figures

Figure 1
Figure 1
Problems with the controls. A page from the lab book.
Figure 2
Figure 2
Learning the nomenclature. Entries in the lab book use ITP as an abbrieviation for inositol 1,4,5-trisphosphate. (a) Summary of experimental data in a spreadsheet-free era; (b) An early draft of a figure (top left) uses ITP, not Ins 1 4 5 P3; the later draft of the figure and some photographs of InsP3-activated eggs are also shown.
Figure 2
Figure 2
Learning the nomenclature. Entries in the lab book use ITP as an abbrieviation for inositol 1,4,5-trisphosphate. (a) Summary of experimental data in a spreadsheet-free era; (b) An early draft of a figure (top left) uses ITP, not Ins 1 4 5 P3; the later draft of the figure and some photographs of InsP3-activated eggs are also shown.
See this image and copyright information in PMC

References

    1. Baker PF, Blaustein MP, Hodgkin AL, Steinhardt RA. The influence of calcium on sodium efflux in squid axons. J Physiol. 1969;200:431–58. - PMC - PubMed
    1. Katz B, Miledi R. The effect of prolonged depolarization on synaptic transfer in the stellate ganglion of the squid. J Physiol. 1971;216:503–12. - PMC - PubMed
    1. Baker PF, Presley R. Kinetic evidence for an intermediate stage in the fertilization of the sea urchin egg. Nature. 1969;221:488–90. - PubMed
    1. Vacquier VD. The isolation of intact cortical granules from sea urchin eggs: calcium lons trigger granule discharge. Dev Biol. 1975;43:62–74. - PubMed
    1. Baker PF, Whitaker MJ. Influence of ATP and calcium on the cortical reaction in sea urchin eggs. Nature. 1978;276:513–515. - PubMed

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