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Review
. 2006 May-Jun;1761(5-6):505-8.
doi: 10.1016/j.bbalip.2006.02.008. Epub 2006 Mar 15.

Nuclear inositide signalling -- expansion, structures and clarification

Affiliations
Review

Nuclear inositide signalling -- expansion, structures and clarification

Robin F Irvine. Biochim Biophys Acta. 2006 May-Jun.

Abstract

The extent and content of this review issue highlights how our understanding of lipid signalling in the nucleus has grown, both in what we actually know, and the breadth of signalling pathways that we now have to consider. Here, a few key issues with regard to nuclear inositide signalling are briefly addressed.

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References

    1. Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, Irvine RF. Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J. 1987;248:765–70. - PMC - PubMed
    1. Irvine RF. Nuclear lipid signalling. Nat Rev Mol Cell Biol. 2003;4:349–60. - PubMed
    1. Divecha N, Banfic H, Irvine RF. The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. Embo J. 1991;10:3207–14. - PMC - PubMed
    1. Cullen PJ, Cozier GE, Banting G, Mellor H. Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking. Curr Biol. 2001;11:R882–893. - PubMed
    1. Hunt AN, Clark GT, Attard GS, Postle AD. Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes. J Biol Chem. 2001;276:8492–8499. - PubMed

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