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. 1991 Nov;86(2):299-303.
doi: 10.1111/j.1365-2249.1991.tb05813.x.

Neutrophil chemotactic factor produced by Japanese encephalitis virus stimulated macrophages

N Khanna  1 , M Agnihotri, A Mathur, U C Chaturvedi
Affiliations

Neutrophil chemotactic factor produced by Japanese encephalitis virus stimulated macrophages

N Khanna et al. Clin Exp Immunol. 1991 Nov.

Abstract

The mechanism of neutrophil leucocytosis in cases of Japanese encephalitis is not known. We here report that during Japanese encephalitis virus (JEV) infection in mice the splenic macrophages secrete a chemotactic factor that attracts the neutrophils. The peak activity of macrophage derived factor (MDF) was observed on day 7 following infection. The MDF acted in a dose-dependent manner. This chemoattractant was purified by low pressure liquid chromatography and gave a single band of 10 kD on silver stained polyacrylamide gel. The MDF was found to be heat resistant and sensitive to prolonged incubation with proteases.

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References

    1. Ann Neurol. 1985 Nov;18(5):567-73 - PubMed
    1. Ann Neurol. 1986 Dec;20(6):691-5 - PubMed
    1. J Exp Med. 1988 Jun 1;167(6):1939-44 - PubMed
    1. Eur J Immunol. 1989 Jul;19(7):1189-94 - PubMed
    1. Biochem Biophys Res Commun. 1988 Mar 15;151(2):883-90 - PubMed