doi: 10.1111/j.1749-6632.1975.tb29064.x.
Thymosin-induced differentiation of murine thymocytes in allogeneic mixed lymphocyte cultures
- PMID: 165764
- DOI: 10.1111/j.1749-6632.1975.tb29064.x
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Thymosin-induced differentiation of murine thymocytes in allogeneic mixed lymphocyte cultures
Ann N Y Acad Sci.
.
Abstract
Calf thymosin is shown to enhance the one-way MLR of CBA thymocytes cultured with allogeneic mitomycin-C- treated C57BL/J6 spleen cells. Thymosin does not enhance the one-way MLR of CBA thymocytes cultured with syngeneic mitomucin-C-treated spleen cells. Based on this finding we present a relatively simple, rapid and quantitative in vitro microculture hioassay for inducers of T-cell differentiation and propose that thymosin treatment, when accompanied by antigen presentation, induces the two-step maturational sequence of pre-T yields T1 yields T2.
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