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. 1991 Dec;59(12):4706-9.
doi: 10.1128/iai.59.12.4706-4709.1991.

Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice

P B Chen  1 , L B Davern, A Aguirre
Affiliations

Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice

P B Chen et al. Infect Immun. 1991 Dec.

Abstract

The purpose of this report was to study the role of T lymphocytes following injection of Porphyromonas gingivalis in a mouse abscess model. Three invasive P. gingivalis isolates (ATCC 53977, W83, and AJW4) were injected into athymic BALB/c mice and their heterozygous (nu/+) littermates. The athymic BALB/c (nu/nu) mice were able to localize the invasive P. gingivalis isolates at the injection site. By comparison, the heterozygous BALB/c (nu/+) littermates developed hemorrhagic secondary lesions within 24 h after subcutaneous injection of the same invasive P. gingivalis isolates. These results suggest that naive T lymphocytes may contribute to the pathology associated with P. gingivalis infection.

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