doi: 10.1007/s11882-006-0041-4.
Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population
Affiliations
- PMID: 16579875
- DOI: 10.1007/s11882-006-0041-4
Item in Clipboard
Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population
Curr Allergy Asthma Rep.
2006 May.
Abstract
Identifying genes that influence susceptibility to asthma-related and atopy-related phenotypes has been challenging, owing to clinical heterogeneity and a complex underlying genetic architecture that includes both gene-gene and gene-environment interactions. In this article, we report the results of genome-wide linkage and association studies of eight asthma-associated quantitative traits in the Hutterites, a founder population of European descent. Our study revealed significant sex-specific genetic architecture for at least five of these traits, and identified 13 genome-wide significant quantitative trait loci (QTL) by linkage or association that are present in only one of the sexes (nine in males, four in females).
Similar articles
-
The sex-specific genetic architecture of quantitative traits in humans.Nat Genet. 2006 Feb;38(2):218-22. doi: 10.1038/ng1726. Epub 2006 Jan 22. Nat Genet. 2006. PMID: 16429159
-
A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.Am J Hum Genet. 2000 Nov;67(5):1154-62. doi: 10.1016/S0002-9297(07)62946-2. Epub 2000 Oct 5. Am J Hum Genet. 2000. PMID: 11022011 Free PMC article.
-
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma.Hum Mol Genet. 1998 Sep;7(9):1393-8. doi: 10.1093/hmg/7.9.1393. Hum Mol Genet. 1998. PMID: 9700192
-
Susceptibility genes in asthma and allergy.Curr Allergy Asthma Rep. 2001 Mar;1(2):174-9. doi: 10.1007/s11882-001-0085-4. Curr Allergy Asthma Rep. 2001. PMID: 11899300 Review.
-
Meta-analysis of genome-wide linkage studies of asthma and related traits.Respir Res. 2008 Apr 28;9(1):38. doi: 10.1186/1465-9921-9-38. Respir Res. 2008. PMID: 18442398 Free PMC article. Review.
Cited by
-
Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.PLoS One. 2009 Aug 28;4(8):e6827. doi: 10.1371/journal.pone.0006827. PLoS One. 2009. PMID: 19714249 Free PMC article.
-
A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.Mol Pain. 2008 Apr 16;4:13. doi: 10.1186/1744-8069-4-13. Mol Pain. 2008. PMID: 18416828 Free PMC article.
-
Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip.Front Genet. 2014 Aug 5;5:222. doi: 10.3389/fgene.2014.00222. eCollection 2014. Front Genet. 2014. PMID: 25147553 Free PMC article.
-
The CRTh2 polymorphism rs533116 G > A associates with asthma severity in older females.Front Med (Lausanne). 2022 Oct 13;9:970495. doi: 10.3389/fmed.2022.970495. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36314028 Free PMC article.
-
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.Transl Res. 2008 Mar;151(3):141-53. doi: 10.1016/j.trsl.2007.12.008. Epub 2008 Jan 18. Transl Res. 2008. PMID: 18279813 Free PMC article.