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. 2006 Apr;113(4):657-60.
doi: 10.1016/j.ophtha.2006.01.007.

Optical coherence tomography findings in stage 4A retinopathy of prematurity: a theory for visual variability

Mandar M Joshi  1 , Michael T Trese, Antonio Capone Jr
Affiliations

Optical coherence tomography findings in stage 4A retinopathy of prematurity: a theory for visual variability

Mandar M Joshi et al. Ophthalmology. 2006 Apr.

Abstract

Purpose: To report macular anatomic abnormalities in eyes with stage 4A retinopathy of prematurity (ROP) that may account for poor visual outcome despite an ophthalmoscopically normal-appearing posterior pole.

Design: Retrospective case series.

Participants: Nine patients (14 eyes).

Methods: Nine patients (14 eyes) diagnosed with stage 4A retinal detachments were imaged with optical coherence tomography (OCT) before repair by lens-sparing pars plana vitrectomy. One patient (2 eyes) 2 years after successful lens-sparing vitrectomy for stage 4A detachment with reduced visual acuity underwent fluorescein angiography, fundus photography, and imaging with OCT.

Main outcome measure: Optical coherence tomography findings.

Results: Preoperative OCT confirmed absence of macular involvement in 12 of 14 eyes. Two eyes demonstrated diffuse intraretinal posterior pole changes. Both eyes of a 2-year-old infant demonstrated a lack of normal foveal architecture on OCT scanning and an absent foveal avascular zone on angiography.

Conclusions: Anatomic macular abnormalities--not immediately apparent ophthalmoscopically--may explain the variability in visual outcome after lens-sparing vitrectomy for stage 4A ROP.

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