Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 May;38(5):556-60.
doi: 10.1038/ng1770. Epub 2006 Apr 2.

Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies

Susan Service  1 , Joseph DeYoung, Maria Karayiorgou, J Louw Roos, Herman Pretorious, Gabriel Bedoya, Jorge Ospina, Andres Ruiz-Linares, António Macedo, Joana Almeida Palha, Peter Heutink, Yurii Aulchenko, Ben Oostra, Cornelia van Duijn, Marjo-Riitta Jarvelin, Teppo Varilo, Lynette Peddle, Proton Rahman, Giovanna Piras, Maria Monne, Sarah Murray, Luana Galver, Leena Peltonen, Chiara Sabatti, Andrew Collins, Nelson Freimer
Affiliations

Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies

Susan Service et al. Nat Genet. 2006 May.

Abstract

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.

PubMed Disclaimer

Publication types