Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Aug;69(8):2155-9.
doi: 10.1073/pnas.69.8.2155.

Catalytic accelerations of 10-fold by an enzyme-like synthetic polymer

H C Kiefer  1 , W I Congdon, I S Scarpa, I M Klotz
Affiliations

Catalytic accelerations of 10-fold by an enzyme-like synthetic polymer

H C Kiefer et al. Proc Natl Acad Sci U S A. 1972 Aug.

Abstract

A synthetic polymer, polyethyleneimine containing dodecyl (C(12)H(25))-chains for binding sites and imidazole moieties for functional catalytic groups, catalyzes the hydrolysis of phenolic sulfate esters by a two-step mechanism resembling that of the corresponding natural enzyme. Quantitative rate studies give kinetic parameters that show that the polymer (synzyme) accelerates the rate 10(12)-fold compared to unbound imidazole, and 10(2)-fold compared to a type IIA aryl sulfatase enzyme.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochim Biophys Acta. 1969 Mar;175(2):355-64 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Feb;68(2):263-4 - PubMed
    1. Biochem J. 1952 May;51(2):202-8 - PubMed
    1. Biochemistry. 1969 Dec;8(12):4752-6 - PubMed
    1. Biochim Biophys Acta. 1971 Jan 13;227(1):129-38 - PubMed

LinkOut - more resources