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. 1974 Mar;71(3):793-6.
doi: 10.1073/pnas.71.3.793.

The Secretion of alpha-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro

D S King  1 , W E Bollenbacher, D W Borst, W V Vedeckis, J D O'connor, P I Ittycheriah, L I Gilbert
Affiliations

The Secretion of alpha-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro

D S King et al. Proc Natl Acad Sci U S A. 1974 Mar.

Abstract

Prothoracic glands of tobacco hornworm larvae cultured in vitro secrete into the culture medium a substance which was active in ecdysone bioassays and determined to be ecdysone-like by radioimmunoassay. The prothoracic glands appear to be the sole source of this substance. The material was identified as alpha-ecdysone by thin-layer, gas-liquid, and high-resolution liquid chromatography and mass spectrometry. No other active moulting principles were present in the medium. It appears that the prothoracic gland secretes a prohormone, alpha-ecdysone, which is subsequently converted into the active moulting hormone, beta-ecdysone, in other insect tissues.

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References

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