Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Oct;78(10):5919-23.
doi: 10.1073/pnas.78.10.5919.

Steric control of CO binding in a totally synthetic heme protein model

D H Busch  1 , L L Zimmer, J J Grzybowski, D J Olszanski, S C Jackels, R C Callahan, G G Christoph
Affiliations

Steric control of CO binding in a totally synthetic heme protein model

D H Busch et al. Proc Natl Acad Sci U S A. 1981 Oct.

Abstract

A family of totally synthetic models for the carbon monoxide adducts of heme proteins has been synthesized and applied to the elucidation of the role of steric effects in the relative detoxification of carbon monoxide. The complexes are designed such that a sheltered void of controllable dimensions encompasses the CO binding site. Systematic variations in the available space for the iron-bound CO produce a wide range of equilibrium binding constants (K(CO)). An x-ray structure determination of a CO adduct complex having a crowded CO site reveals that the Fe-C identical withO linkage is bent, and further, the distortion involves both displacement of the Fe-C vector from the normal to the N(4) plane and bending of the Fe-C-O angle.

PubMed Disclaimer

References

    1. Annu Rev Biochem. 1979;48:327-86 - PubMed
    1. J Mol Biol. 1979 Jan 25;127(3):309-38 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5387-92 - PubMed
    1. J Mol Biol. 1976 Jul 5;104(3):707-22 - PubMed
    1. Br Med Bull. 1976 Sep;32(3):193-4 - PubMed

LinkOut - more resources