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. 1982 Jun;79(12):3769-72.
doi: 10.1073/pnas.79.12.3769.

Cycloartenol-derived sterol biosynthesis in the Peronosporales

S A Warner  1 , D F Eierman, G W Sovocool, A J Domnas
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Cycloartenol-derived sterol biosynthesis in the Peronosporales

S A Warner et al. Proc Natl Acad Sci U S A. 1982 Jun.

Abstract

Selected species of the order Peronosporales, which are unable to epoxidize squalene and thus synthesize sterols, are able to metabolize exogenous cycloartenol to lanosterol and in some organisms to fucosterol, ergosterol, and cholesterol. Lanosterol was less effectively utilized but some ergosterol and cholesterol were yielded. Fucosterol was very efficiently metabolized by most species to ergosterol, Delta(7)-ergostenol, Delta(5)-ergostenol, cholestanol, and cholesterol. Several unknown sterols were observed in most trials. These data suggest a vestigial sterol synthetic pathway derived from cycloartenol, followed by possible isomerization to lanosterol and then to other sterols.

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