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. 1986 Oct;83(20):7821-5.
doi: 10.1073/pnas.83.20.7821.

Toward a physical map of the genome of the nematode Caenorhabditis elegans

A Coulson  1 , J Sulston, S Brenner, J Karn
Affiliations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

A Coulson et al. Proc Natl Acad Sci U S A. 1986 Oct.

Abstract

A technique for digital characterization and comparison of DNA fragments, using restriction enzymes, is described. The technique is being applied to fragments from the nematode Caenorhabditis elegans (i) to facilitate cross-indexing of clones emanating from different laboratories and (ii) to construct a physical map of the genome. Eight hundred sixty clusters of clones, from 35 to 350 kilobases long and totaling about 60% of the genome, have been characterized.

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References

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