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Comparative Study
. 2007 Apr;28(4):519-23.
doi: 10.1016/j.neurobiolaging.2006.02.011. Epub 2006 Apr 3.

A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers

María J Bullido  1 , Ana Martínez-García, María J Artiga, Jesús Aldudo, Isabel Sastre, Pedro Gil, Francisco Coria, David G Muñoz, Vladimir Hachinski, Ana Frank, Fernando Valdivieso
Affiliations
Comparative Study

A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers

María J Bullido et al. Neurobiol Aging. 2007 Apr.

Abstract

Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.

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