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. 2006 May;111(3):193-8.
doi: 10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2.

Mortality in Prader-Willi syndrome

Stewart L Einfeld  1 , Sophie J Kavanagh, Arabella Smith, Elizabeth J Evans, Bruce J Tonge, John Taffe
Affiliations

Mortality in Prader-Willi syndrome

Stewart L Einfeld et al. Am J Ment Retard. 2006 May.

Abstract

Persons with Prader-Willi syndrome have been known to have a high mortality rate. However, intellectual disability, which usually accompanies Prader-Willi syndrome, is also associated with a higher mortality rate than in the general population. In this study, the death rates in a longitudinal cohort of people with Prader-Willi syndrome are compared with those for an epidemiologically derived control sample of people with intellectual disability from other causes. We found that those with Prader-Willi syndrome had a higher mortality rate than did controls. After the protective effect of mild intellectual disability or average intellectual function was accounted for, the hazard ratio for Prader-Willi syndrome versus controls was 6.07. Obesity and its complications were factors contributing to the mortality identified in this study.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival estimates for control group and Prader-Willi syndrome group.
Figure 2
Figure 2
Kaplan-Meier survival estimates for control group and Prader-Willi syndrome group with confidence intervals.
See this image and copyright information in PMC

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