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. 2006 Apr;44(4):1561-3.
doi: 10.1128/JCM.44.4.1561-1563.2006.

Early detection of hepatitis C virus infection by use of a new combined antigen-antibody detection assay: potential use for high-risk individuals

A Schnuriger  1 , S Dominguez, M-A Valantin, R Tubiana, C Duvivier, J Ghosn, A Simon, C Katlama, V Thibault
Affiliations

Early detection of hepatitis C virus infection by use of a new combined antigen-antibody detection assay: potential use for high-risk individuals

A Schnuriger et al. J Clin Microbiol. 2006 Apr.

Abstract

The performance of a new combined antigen-antibody assay (Monolisa HCV Ag-Ab Ultra; Bio-Rad Laboratories) was evaluated in the context of acute hepatitis C in human immunodeficiency virus-infected patients. The combined assay became positive as early as the first PCR and earlier than a third-generation enzyme-linked immunosorbent assay in 65% of the cases. Reduction of the long period of HCV seronegativity should improve the diagnosis of hepatitis C infection, especially in high-risk populations.

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References

    1. Alter, M. J., W. L. Kuhnert, and L. Finelli. 2003. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Morb. Mortal. Wkly. Rep. Recomm. Rep. 52:1-13, 15. - PubMed
    1. Ansaldi, F., B. Bruzzone, G. Testino, M. Bassetti, R. Gasparini, P. Crovari, and G. Icardi. 2006. Combination hepatitis C virus antigen and antibody immunoassay as a new tool for early diagnosis of infection. J. Viral Hepat. 13:5-10. - PubMed
    1. Bouvier-Alias, M., K. Patel, H. Dahari, S. Beaucourt, P. Larderie, L. Blatt, C. Hezode, G. Picchio, D. Dhumeaux, A. U. Neumann, J. G. McHutchison, and J. M. Pawlotsky. 2002. Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication. Hepatology 36:211-218. - PubMed
    1. Bukh, J., R. H. Purcell, and R. H. Miller. 1994. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc. Natl. Acad. Sci. USA 91:8239-8243. - PMC - PubMed
    1. Gerlach, J. T., H. M. Diepolder, R. Zachoval, N. H. Gruener, M. C. Jung, A. Ulsenheimer, W. W. Schraut, C. A. Schirren, M. Waechtler, M. Backmund, and G. R. Pape. 2003. Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance. Gastroenterology 125:80-88. - PubMed

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