Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Apr;44(4):1571-4.
doi: 10.1128/JCM.44.4.1571-1574.2006.

Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles

Katherine N Ward  1 , Hoe Nam Leong, Elisabeth P Nacheva, Julie Howard, Claire E Atkinson, Nicholas W S Davies, Paul D Griffiths, Duncan A Clark
Affiliations

Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles

Katherine N Ward et al. J Clin Microbiol. 2006 Apr.

Abstract

Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and beta-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log(10) copies/milliliter) in blood was 7.0 (>/=1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (>/=1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log(10) copies)/hair follicle was 4.2 (>/=1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.

PubMed Disclaimer

References

    1. Ablashi, D., H. Agut, Z. N. Berneman, F. G. Campadelli, D. R. Carrigan, N. L. Ceccherini, B. Chandran, S. Chou, H. Collandre, R. W. Cone, T. R. Dambaugh, S. Dewhurst, D. Di Luca, L. Foa-Thomasi, B. Fleckenstein, N. Frenkel, R. C. Gallo, U. A. Gompels, C. B. Hall, M. Jones, G. L. Lawrence, M. Martin, L. Montaigner, F. Neipel, J. C. Nicolas, P. Pellett, A. Razzaque, G. Torelli, B. Thomson, S. Z. Salahuddin, L. S. Wyatt, and K. Yamanishi. 1993. Human herpesvirus-6 strain groups: a nomenclature. Arch. Virol. 129:363-366. - PubMed
    1. Caserta, M. T., M. P. McDermott, S. Dewhurst, K. Schnabel, J. A. Carnahan, L. Gilbert, G. Lathan, G. K. Lofthus, and C. B. Hall. 2004. Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J. Pediatr. 145:478-484. - PubMed
    1. Clark, D. A., M. Ait-Khaled, A. C. Wheeler, I. M. Kidd, J. E. McLaughlin, M. A. Johnson, P. D. Griffiths, and V. C. Emery. 1996. Quantification of human herpesvirus 6 in immunocompetent persons and post-mortem tissues from AIDS patients by PCR. J. Gen. Virol. 77:2271-2275. - PubMed
    1. Clark, D. A., E. P. Nacheva, H. N. Leong, D. Brazma, Y. T. Li, E. H. F. Tsao, H. C. E. Buyck, C. E. Atkinson, H. M. Lawson, M. N. Potter, and P. D. Griffiths. 2006. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. J. Infect. Dis. 193:912-916. - PubMed
    1. Daibata, M., T. Taguchi, Y. Nemoto, H. Taguchi, and I. Miyoshi. 1999. Inheritance of chromosomally integrated human herpesvirus 6 DNA. Blood 94:1545-1549. - PubMed

Publication types

LinkOut - more resources