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Case Reports
. 2006 Apr;44(4):1584-6.
doi: 10.1128/JCM.44.4.1584-1586.2006.

Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman

Todd Czartoski  1 , Charlie Liu, David M Koelle, Stephen Schmechel, Andrea Kalus, Anna Wald
Affiliations
Case Reports

Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman

Todd Czartoski et al. J Clin Microbiol. 2006 Apr.

Abstract

We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.

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Figures

FIG. 1.
FIG. 1.
Serum aspartate aminotransferase (AST) and total bilirubin during hospitalization with plasma and peritoneal HSV levels as determined by PCR. Recurrent elevation of bilirubin and AST levels coincided with a switch to valacyclovir. Arrows indicate changes in antiviral therapy. IV ACV, intravenous acyclovir; VACV, oral valacyclovir.
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