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Case Reports
. 2006 Apr;44(4):1590-1.
doi: 10.1128/JCM.44.4.1590-1591.2006.

Fluoroquinolone resistance in Ureaplasma parvum in the United States

Lynn Duffy  1 , John Glass, Geraldine Hall, Robin Avery, Raymond Rackley, Scott Peterson, Ken Waites
Affiliations
Case Reports

Fluoroquinolone resistance in Ureaplasma parvum in the United States

Lynn Duffy et al. J Clin Microbiol. 2006 Apr.

Abstract

We report the first case of naturally occurring fluoroquinolone resistance in Ureaplasma spp. from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure.

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References

    1. Bebear, C. M., H. Renaudin, A. Charron, M. Clerc, S. Pereyre, and C. Bebear. 2003. DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones. Antimicrob Agents Chemother. 47:3323-3325. - PMC - PubMed
    1. Bebear, C. M., H. Renaudin, A. Charron, D. Gruson, M. Lefrancois, and C. Bebear. 2000. In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob Agents Chemother. 44:2557-2560. - PMC - PubMed
    1. Bowie, W. R., and V. Willetts. 1987. Suboptimal efficacy of erythromycin and tetracycline against vaginal Ureaplasma urealyticum. Sex Transm. Dis. 14:88-91. - PubMed
    1. Dhandayuthapani, S., M. W. Blaylock, C. M. Bebear, W. G. Rasmussen, and J. B. Baseman. 2001. Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium. J. Bacteriol. 183:5645-5650. - PMC - PubMed
    1. Dhandayuthapani, S., W. G. Rasmussen, and J. B. Baseman. 1999. Disruption of gene mg218 of Mycoplasma genitalium through homologous recombination leads to an adherence-deficient phenotype. Proc. Natl. Acad. Sci. USA 96:5227-5232. - PMC - PubMed

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