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. 2006 Apr;72(4):3050-3.
doi: 10.1128/AEM.72.4.3050-3053.2006.

Safety assessment of the oral cavity probiotic Streptococcus salivarius K12

Jeremy P Burton  1 , Philip A Wescombe, Chris J Moore, Chris N Chilcott, John R Tagg
Affiliations

Safety assessment of the oral cavity probiotic Streptococcus salivarius K12

Jeremy P Burton et al. Appl Environ Microbiol. 2006 Apr.

Abstract

Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.

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Figures

FIG. 1.
FIG. 1.
Streptococcus salivarius K12 (even-numbered lanes) and S. pyogenes SF370 (odd-numbered lanes) amplification products resulting from PCR using specific primers for the sagA (lanes 2 and 3), scpA (lanes 5 and 6), smez-2 (lanes 8 and 9), speB (lanes 11 and 12), and emm (lanes 14 and 15) genes. Lanes 1 and 17, 1-kb marker (Gibco).
FIG. 2.
FIG. 2.
Autoradiographs of Southern blots hybridized with amplicons of the different streptococcal virulence factors (given at the bottom). Lanes containing HindIII-digested DNA from S. pyogenes SF370 are labeled SF370. Lanes containing HindIII-digested DNA from S. salivarius strain K12 are labeled K12.
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