Review
[Tumor suppressor genes: occurrence, significance and function]
[Article in
German]
Affiliations
- PMID: 1660097
Item in Clipboard
Review
[Tumor suppressor genes: occurrence, significance and function]
[Article in
German]
Monatsschr Kinderheilkd.
1991 Oct.
Abstract
Tumor-suppressor-genes were detected by DNA-analysis of childhood tumors. A homozygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.
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