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Review
. 1991 Oct;139(10):650-4.

[Tumor suppressor genes: occurrence, significance and function]

[Article in German]
W Scheurlen  1 , H W Kreth
Affiliations
  • PMID: 1660097
Review

[Tumor suppressor genes: occurrence, significance and function]

[Article in German]
W Scheurlen et al. Monatsschr Kinderheilkd. 1991 Oct.

Abstract

Tumor-suppressor-genes were detected by DNA-analysis of childhood tumors. A homozygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.

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