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Comment
. 2006 Apr 7;312(5770):55; author reply 55.
doi: 10.1126/science.1115362.

Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"

Thomas Gruber  1 , Michael Freeley, Nikolaus Thuille, Isabelle Heit, Stephen Shaw, Aideen Long, Gottfried Baier
Affiliations
Comment

Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"

Thomas Gruber et al. Science. .

Abstract

We observe that protein kinase C (PKC) is phosphorylated on the activation loop at threonine 538 (Thr-538) before T cell activation. Our results are inconsistent with the conclusions of Lee et al. (Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKC is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKC in T cells.

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