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. 2006;21(3):314-8.
doi: 10.1159/000091363.

Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias

Thomas Kohl  1 , Ulrich Gembruch, Barbara Filsinger, Rudolf Hering, Jorgen Bruhn, Kristina Tchatcheva, Sebastian Aryee, Axel Franz, Axel Heep, Andreas Muller, Peter Bartmann, Stefan Loff, Stuart Hosie, Wolfgang Neff, Thomas Schaible; German Center for Fetal Surgery Diaphragmatic Hernia Task Group
Affiliations

Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias

Thomas Kohl et al. Fetal Diagn Ther. 2006.

Abstract

Objective: In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia.

Methods: Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients.

Results: Six of the 8 fetuses survived to discharge from hospital.

Conclusion: Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.

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