Review
doi: 10.1111/j.1749-6632.1991.tb36478.x.
Enzymatic gating of voltage-activated calcium channels
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- PMID: 1660238
- DOI: 10.1111/j.1749-6632.1991.tb36478.x
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Review
Enzymatic gating of voltage-activated calcium channels
Ann N Y Acad Sci.
1991.
Abstract
The model of calcium-channel gating described above, although almost certainly too simple, suggests a direct role for protein kinases and phosphatases in determining the kinetics of calcium channel gating on a subsecond time scale. In addition, it provides a unique perspective for understanding studies of calcium channel gating under widely different metabolic and pharmacological conditions. Although many of these effects may be specific to the dihydropyridine-sensitive or L-type calcium channel, they give an indication of the range of possibilities for integrating calcium-channel activity with cellular biochemistry.
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