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Multicenter Study
. 2006 Apr;124(4):529-35.
doi: 10.1001/archopht.124.4.529.

Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)

Cristina A Augood  1 , Johannes R Vingerling, Paulus T V M de Jong, Usha Chakravarthy, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Graham Bentham, Mati Rahu, Jesus Vioque, Ian S Young, Astrid E Fletcher
Affiliations
Multicenter Study

Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)

Cristina A Augood et al. Arch Ophthalmol. 2006 Apr.

Abstract

Objective: To estimate the prevalence of age-related maculopathy in an older population from 7 European countries.

Methods: Randomly sampled people 65 years and older were invited to an eye examination in centers across 7 European countries (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain). Fundus images of each eye were graded at a single reading center. Prevalence rates were calculated for stage of age-related maculopathy with 95% confidence intervals (CIs) estimated for clustered data.

Results: Of 5040 participants (45% response rate), 4753 (2128 men and 2625 women) had gradable fundus images. The prevalences were grade 0, 47.59% (95% CI, 43.53%-51.65%); grade 1, 36.48% (95% CI, 32.66%-40.30%); grade 2, 10.14% (95% CI, 8.92% to 11.37%); grade 3, 2.46% (95% CI, 1.79%-3.13%); and grade 4 (age-related macular degeneration [AMD]), 3.32% (95% CI, 2.52%-4.13%) and large drusen only (> or = 125 microm), 15.41% (95% CI, 13.61%-17.21%). The prevalence of geographic atrophic AMD was 1.2% (95% CI, 0.8%-1.7%) and of neovascular AMD, 2.3% (95% CI, 1.7%-2.9%). The prevalence of bilateral AMD was 1.4% (95% CI, 1.0%-1.8%).

Conclusion: Age-specific prevalences of age-related maculopathy in the European Eye Study (EUREYE) are similar to other population-based studies in Western populations.

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